刘峰副教授在Org Lett上发表署名论文Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of Valdecoxib and Oxacillin.
ABSTRACT: A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported.
